PARENTERALS

 INTRODUCTION

The Parenteral refers to injectable route of administration. It derived from a Greek word Para (means outside), enteron (means intestine) & Dentons (route of administration other than oral route).

DEFINITION

Parenteral preparations or injectables are the sterile solutions or suspensions of drugs in aqueous or oily vehicles meant for introduction into the body by means of an injection under or through one or more layers of the skin or mucous membrane.

OFFICIAL TYPES OF INJECTABLES

According to the USP, injectable materials are separate into five general types. These may contain buffers, preservatives, and other added substances.

1. Injection

2. For injection

3. Injectable Emulsion

4. Injectable Suspension

5. For Injectable Suspension

1. Injection:

Liquid preparations that are drug substances or solutions thereof (e.g., Insulin Injection, USP).

2. For injection:

Dry solids that, upon addition of suitable vehicles, yield solutions conforming in all respects to the requirements for injections (e.g., Cefuroxime for injection, USP).

3. Injectable emulsion:

Liquid preparation of drug substance dissolved or dispersed in a suitable emulsion medium (e.g., Propofol, USP).

4. Injectable suspension:

Liquid preparation of solid suspended in a suitable liquid medium (e.g., Methylprednisolone Acetate Suspension, USP).

5. For injectable suspension:

Dry solid that, upon addition of suitable vehicle, yields preparation conforming in all respects to the requirements for injectable suspensions (e.g., Imipenem and Cilastatin for injectable suspension, USP).